abstract：:Percutaneous delivery of NSAIDs has advantages of avoiding hepatic first pass effect and delivering the drug for extended period of time at a sustained, concentrated level at the inflammation site that mainly acts at the joint and the related regions. To develop the new topical formulations of pranoprofen that have su...

journal_title：Archives of pharmacal research

authors： Shin SC,Cho CW

更新日期：2006-10-01 00:00:00

abstract：:Danshen is an herbal medication frequently used in oriental medicine to treat liver or kidney malfunction. In the course of our studies, we observed that compounds purified from Danshen exhibit an inhibitory activity against Discoidin Domain Receptor 2 (DDR2) tyrosine kinase. Through this inhibition, these compounds a...

journal_title：Archives of pharmacal research

authors： Oh SH,Cho KH,Yang BS,Roh YK

更新日期：2006-09-01 00:00:00

abstract：:This study examined the chemopreventive effect of saponins that were isolated from the roots of Platycodon grandiflorum A. DC (Campanulaceae), Changkil saponins (CKS), against the tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), -on lung tumorigenesis in A/J mice. The mice were treate...

journal_title：Archives of pharmacal research

authors： Lee KJ,Shin DW,Chung YC,Jeong HG

更新日期：2006-08-01 00:00:00

abstract：:Three naphthopyrone glucosides, cassiaside (1), rubrofusarin-6-O-beta-D-gentiobioside (2), and toralactone-9-O-beta-D-gentiobioside (3), were isolated from the BuOH-soluble extract of the seeds of Cassia tora as active constituents, using an in vitro bioassay based on the inhibition of advanced glycation end products ...

journal_title：Archives of pharmacal research

authors： Lee GY,Jang DS,Lee YM,Kim JM,Kim JS

更新日期：2006-07-01 00:00:00

abstract：:As we approach the completion of the first 25 years of the human immunodeficiency virus (HIV) epidemic, there have been dramatic improvements in the care of patients with HIV infection. These have prolonged life and decreased morbidity. There are twenty currently available antiretrovirals approved in the United States...

journal_title：Archives of pharmacal research

authors： Samuel R,Bettiker R,Suh B

更新日期：2006-06-01 00:00:00

abstract：:The effect of acteoside, a phenylpropanoid glycoside isolated from Clerodendron trichotomum Thunberg, on histamine and arachidonic acid release was investigated in RBL 2H3 cells. Histamine was dose-dependently released from RBL 2H3 cells by melittin, arachidonic acid and thapsigargin. In extracellular Ca2+-free soluti...

journal_title：Archives of pharmacal research

authors： Lee JH,Lee JY,Kang HS,Jeong CH,Moon H,Whang WK,Kim CJ,Sim SS

更新日期：2006-06-01 00:00:00

abstract：:EGCG [(-)-epigallocatechin-3-gallate], a major component of green tea has been considered as a major antioxidant constituent. In addition to having been considered for cancer treatment as a chemopreventive and chemotherapeutic agent, EGCG has recently been attributed an anti-proliferative effect. We re-examined the la...

journal_title：Archives of pharmacal research

authors： Ji SJ,Han DH,Kim JH

更新日期：2006-05-01 00:00:00

abstract：:In the developing brain, capillaries are differentiated and matured into the blood-brain barrier (BBB), which is composed of cerebral endothelial cells, astrocyte end-feet, and pericytes. Since the BBB regulates the homeostasis of central nervous system (CNS), the maintenance of the BBB is important for CNS function. ...

journal_title：Archives of pharmacal research

authors： Lee SW,Kim WJ,Park JA,Choi YK,Kwon YW,Kim KW

更新日期：2006-04-01 00:00:00

abstract：:The bioequivalence and pharmacokinetics of alendronate sodium tablets were examined by determining the plasma concentration of alendronate. Two groups, consisting of 24 healthy volunteers, each received a 70 mg reference alendronate sodium tablet and a test tablet in a 2x2 crossover study. There was a 6-day washout pe...

journal_title：Archives of pharmacal research

authors： Yun MH,Woo JS,Kwon KI

更新日期：2006-04-01 00:00:00

abstract：:Slavins A (1) and B (2), the new amyrin type triterpenes, have been isolated from the chloroform soluble fraction of Salvia santolinifolia and assigned structures on the basis of spectral studies including 2D NMR. Both the compounds displayed inhibitory potential against the enzyme butyrylcholinesterase. ...

journal_title：Archives of pharmacal research

authors： Mehmood S,Riaz N,Nawaz SA,Afza N,Malik A,Choudhary MI

更新日期：2006-03-01 00:00:00

abstract：:Salicornia herbacea L. (Chenopodiaceae) has been used as a seasoned vegetable by living in coastal areas. S. herbacea (SH) has been demonstrated to stimulate cytokine production, nitric oxide release, and to show anti-oxidative effect. In a series of investigations to develop potential anti-diabetic and/or anti-hyperl...

journal_title：Archives of pharmacal research

authors： Park SH,Ko SK,Choi JG,Chung SH

更新日期：2006-03-01 00:00:00

abstract：:To examine a possible synergistic role for p73 and cisplatin (cis-diamminedichloroplatinum II) in HeLa cells with a nonfunctional p53 protein, we established stable HeLa/p73 clones using a tetracycline inducible eukaryotic expression vector. The HeLa/p73 clones were not characterized by changes in growth or morphology...

journal_title：Archives of pharmacal research

authors： Kim KC,Jung CS,Choi KH

更新日期：2006-02-01 00:00:00

abstract：:The antispasmodic and vasodilator activities of a newly synthesized piperidine derivative (1-(4'-fluorophenacyl)-4-hydroxy-4-phenyl-piperidinium chloride) were studied in vitro. The test compound exhibited a dose-dependent relaxant effect on the spontaneous and K+ (75 mM)-induced contractions of isolated rabbit jejunu...

journal_title：Archives of pharmacal research

authors： Taqvi SI,Ghayur MN,Gilani AH,Saify ZS,Aftab MT

更新日期：2006-01-01 00:00:00

abstract：:Phytoestrogens have been used as a food supplement to prevent osteoporosis. The isoflavones in the phytoestrogens are daidzein, genistein and formononetin which are present in various herbs. This study examined the quantity of isoflavones in medicinal herbs, which can be used as a phytoestrogen supplement; soybean. Th...

journal_title：Archives of pharmacal research

authors： Ha H,Lee YS,Lee JH,Choi H,Kim C

更新日期：2006-01-01 00:00:00

abstract：:The antiestrogenic effects of marijuana smoke condensate (MSC) and three major cannabinoids, ie., delta9-tetrahydrocannabinol (THC), cannabidiol (CBD), and cannabinol (CBN), were evaluated using in vitro bioassays, viz., the human breast cancer cell proliferation assay, the recombinant human estrogen receptor (ER) com...

journal_title：Archives of pharmacal research

authors： Lee SY,Oh SM,Lee SK,Chung KH

更新日期：2005-12-01 00:00:00

abstract：:The anti-inflammatory activity of Eurya emarginata (Thumb) Makino, of which leaves have been traditionally used to treat ulcers or diuretic in Jeju Island, has been investigated in the present study. Through the phytochemical study from the methanol extract of E. emaginiata, eutigosides B and C were isolated as the ac...

journal_title：Archives of pharmacal research

authors： Park SY,Lee HJ,Yoon WJ,Kang GJ,Moon JY,Lee NH,Kim SJ,Kang HK,Yoo ES

更新日期：2005-11-01 00:00:00

abstract：:To better define the relationship between dermal regeneration and wound contraction and scar formation, the effects of epidermal growth factor (EGF) loaded in collagen sponge matrix on the fibroblast cell proliferation rate and the dermal mechanical strength were investigated. Collagen sponges with acid-soluble fracti...

journal_title：Archives of pharmacal research

authors： Lee AR

更新日期：2005-11-01 00:00:00

abstract：:A new naturally occurring sterol, compound 5, and six known stigmasterols were isolated from fruits of Ailanthus altissima Swingle by repeated column chromatography and RP-HPLC. Their structures were identified as, 5alpha-stigmastane-3,6-dione (1), 3beta-hydroxystigmast-5-en-7-one (2), stigmast-5-ene-3beta, 7alpha-dio...

journal_title：Archives of pharmacal research

authors： Zhao CC,Shao JH,Li X,Xu J,Zhang P

更新日期：2005-10-01 00:00:00

abstract：:Risperidone has been reported to have neuroleptic activity. In this study, risperidone was synthesized using a new method involving a stille reaction, in which 2-methyl-3-vinyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one was synthesized (5). The chemical synthesis process was found to be simple and produced risperi...

journal_title：Archives of pharmacal research

authors： Kim DM,Kang MS,Kim JS,Jeong JH

更新日期：2005-09-01 00:00:00

abstract：:A presenilin 2 mutation is believed to be involved in the development of Alzheimer's disease. In addition, transgenic mice with a presenilin 2 mutation have been reported to have learning and memory impairments. In this study, exposing PC12 cells expressing mutant presenilin 2 to 50 microM AP25-35, 30 mM L-glutamate a...

journal_title：Archives of pharmacal research

authors： Nguyen HN,Hwang DY,Kim YK,Yoon DY,Kim JH,Lee MS,Lee MK,Yun YP,Oh KW,Hong JT

更新日期：2005-09-01 00:00:00

abstract：:A number of wogonin derivatives have been synthesized as congeners of wogonin and evaluated for their inhibitory activities of PGE2 production. Wogonin derivatives modified at the B ring of wogonin were obtained from 2,4-Dihydroxy-3,6-dimethoxyacetophenone (1) via several steps. Most wogonin derivatives exhibited much...

journal_title：Archives of pharmacal research

authors： Jang J,Sin KS,Kim HP,Park H

更新日期：2005-08-01 00:00:00

abstract：:In this trial we assessed the effect of soluble alginates on murine cells. Mouse peritoneal monocytes were stimulated in vitro with a solution of alginate. The production of TNF-alpha and nitric oxide (NO), the expression of surface molecules CD80 and CD86, and the ability of monocytes to phagocyte bacteria were asses...

journal_title：Archives of pharmacal research

authors： Pasquali P,Zalcman A,Murtas S,Adone R,Brambilla G,Marianelli C,Cagiola M,Ciuchini F

更新日期：2005-08-01 00:00:00

abstract：:This study investigated the stimulative or sedative effects of inhaling fragrant essential oils (EOs) by using a forced swimming test (FST) with mice. This behavioral test is commonly used to measure the effects of antidepressant drugs. The inhalation by mice of EOs, such as ginger oil (p<0.05), thyme oil (p<0.05), pe...

journal_title：Archives of pharmacal research

authors： Lim WC,Seo JM,Lee CI,Pyo HB,Lee BC

更新日期：2005-07-01 00:00:00

abstract：:Synurus deltoides was previously found to possess significant anti-inflammatory activity especially against chronic inflammation, and strong analgesic activity in vivo. In this study, new anti-inflammatory formulation containing S. deltoides extract as a major ingredient was prepared and in vivo activity was evaluated...

journal_title：Archives of pharmacal research

authors： Choi YH,Son KH,Chang HW,Bae K,Kang SS,Kim HP

更新日期：2005-07-01 00:00:00

abstract：:This work includes the synthesis of 15 final compounds (6a-h and 7b-h) as prodrugs of 5-ASA in the form of the acid itself, esters and amides linked by an amide linkage through a spacer to the endocyclic ring N of nicotinamide. Also, 15 new intermediate compounds were prepared. The target compounds (6b, 6f, 7b, and 7e...

journal_title：Archives of pharmacal research

authors： Abdel-Alim AA,El-Shorbagi AN,Abdel-Moty SG,Abdel-Allah HH

更新日期：2005-06-01 00:00:00

abstract：:The present study was designed to investigate the effect of naloxone, a well known opioid antagonist, on the secretion of catecholamines (CA) evoked by cholinergic stimulation and membrane-depolarization in the isolated perfused rat adrenal glands, and to establish its mechanism of action. Naloxone (10(-6) approximate...

journal_title：Archives of pharmacal research

authors： Kim OM,Lim GH,Lim DY

更新日期：2005-06-01 00:00:00

abstract：:A new oleanane-triterpene, 3beta-acetoxy-11alpha-benzoyloxy-13beta-hydroxyolean-12-one (1), was isolated along with a known quinone-methide triterpene, pristimerin (2), from the root bark of Siphonodon celastrineus Griff., a Thai medicinal plant of the family Celastraceae. Their structures were determined based on spe...

journal_title：Archives of pharmacal research

authors： Niampoka C,Suttisri R,Bavovada R,Takayama H,Aimi N

更新日期：2005-05-01 00:00:00

abstract：:Polyethylene glycol (PEG) 6000-based solid dispersions (SDs), by incorporating various pharmaceutical excipients or microemulsion systems, were prepared using a fusion method, to compare the dissolution rates and bioavailabilities in rats. The amorphous structure of the drug in SDs was also characterized by powder X-r...

journal_title：Archives of pharmacal research

authors： Heo MY,Piao ZZ,Kim TW,Cao QR,Kim A,Lee BJ

更新日期：2005-05-01 00:00:00

abstract：:The allylthio group of allicin and other organosulfur compounds, isolated from garlic, is considered a pharmacophore, and a key structure component of the molecule, which affords biological activities. In the foregoing studies, various 3-alkoxy-6-allylthiopyridazine derivatives (K-compounds) were synthesized, and thei...

journal_title：Archives of pharmacal research

authors： Kwon SK,Moon A

更新日期：2005-04-01 00:00:00

abstract：:The water content of skin was determined using a FT near infrared (NIR) spectrometer. NIR diffuse reflectance spectra were collected from hairless mouse, in vitro, and from human inner arm, in vivo. It was found that the variation of NIR absorbance band 1450 nm from OH vibration of water and 1940 nm from the combinati...

journal_title：Archives of pharmacal research

authors： Suh EJ,Woo YA,Kim HJ

更新日期：2005-04-01 00:00:00

abstract：:Drug metabolizing enzymes (DMEs) play central roles in the metabolism, elimination and detoxification of xenobiotics and drugs introduced into the human body. Most of the tissues and organs in our body are well equipped with diverse and various DMEs including phase I, phase II metabolizing enzymes and phase III transp...

journal_title：Archives of pharmacal research

authors： Xu C,Li CY,Kong AN

更新日期：2005-03-01 00:00:00

abstract：:The present study was designed to study the difference effects between nicardipine and its two enantiomers on thoracic artery of rabbit. A high-performance liquid chromatographic method was used to prepare the two enantiomers of nicardipine. The thoracic artery of rabbit was removed. The vessels were cut into 3 mm in ...

journal_title：Archives of pharmacal research

authors： Wang S,He L,Yun B

更新日期：2005-03-01 00:00:00

abstract：:(-)-Fumagillol (1), a hydrolysis product of fumagillin, has been synthesized by several group from commercially available 1,2:5,6-di-O-isopropylidene-alpha-D-allofuranose in a highly stereoselective manner. Chiral centers on C5 and C6 came from D-allofuranose and the asymmetric center on C4 was accomplished by 1,3-chi...

journal_title：Archives of pharmacal research

authors： Kim D,Ahn SK,Bae H,Kim HS

更新日期：2005-02-01 00:00:00

abstract：:In our search for monoamine oxidase (MAO) inhibitors from natural resources, we found that the methanol extract of the roots of Sophora flavescens showed an inhibitory effect on mouse brain monoamine oxidase (MAO). Bioactivity-guided isolation of the extract yielded two known flavonoids, formononetin (1) and kushenol ...

journal_title：Archives of pharmacal research

authors： Hwang JS,Lee SA,Hong SS,Lee KS,Lee MK,Hwang BY,Ro JS

更新日期：2005-02-01 00:00:00

abstract：:We evaluated the antiplatelet effects of two classes of ATP-sensitive potassium channel openers (K(ATP) openers) on washed human platelets, and the study's emphasis was on the role of mitochondrial K(ATP) in platelet aggregation. Collagen-induced platelet aggregation was inhibited in a dose dependent manner by lemakal...

journal_title：Archives of pharmacal research

authors： Cho MR,Park JW,Jung IS,Yi KY,Yoo SE,Chung HJ,Yun YP,Kwon SH,Shin HS

更新日期：2005-01-01 00:00:00

abstract：:The objective of this study was to investigate the effects of sodium lauryl sulfate upon the saturation solubility of carbamazepine, its dissolution kinetics, and T50% defined as the time required for dissolving 50% of carbamazepine. Water, 0.1 N-HCl, and phosphate buffers at pH 4.0 and 6.8 containing 0.1, 0.5, 1, and...

journal_title：Archives of pharmacal research

authors： Lee H,Park SA,Sah H

更新日期：2005-01-01 00:00:00

abstract：:Michael addition of certain nucleophiles on alpha, beta-unsaturated ketones 1 led to the formation of adducts 2-7 as well as the reaction of arylidene derivatives with secondary amines afforded the amino compounds 9 and 11. Also, dialkylmalonates were treated with alpha-cyano cinnamide to afford 13. On the other hand,...

journal_title：Archives of pharmacal research

authors： Said MM,Ahmed AA,El-Alfy AT

更新日期：2004-12-01 00:00:00

abstract：:6-methoxydihydrosanguinarine (6ME), a benzophenanthridine alkaloid derived from the methanol extracts of Hylomecon hylomeconoides, showed a dose-dependent effect at 1-10 microM on causing apoptotic cell death in HT29 colon carcinoma cells (IC50 = 5.0+/-0.2 microM). Treatment of HT-29 cells with 6ME resulted in the for...

journal_title：Archives of pharmacal research

authors： Lee YJ,Yin HQ,Kim YH,Li GY,Lee BH

更新日期：2004-12-01 00:00:00

abstract：:A new benzofuran derivative, named gymnastone [5-hydroxy-6-acetyl-2-(2-propane-1,2,3-triol)-benzofuran (1)], was isolated from the aerial part of Gymnaster koraiensis, together with viscidone (2) by repeated column chromatography. The structures of both compounds were identified by physico-chemical and spectral analys...

journal_title：Archives of pharmacal research

authors： Dat NT,Van Kiem P,Cai XF,Shen Q,Bae K,Kim YH

更新日期：2004-11-01 00:00:00

abstract：:We investigated the neurotoxic effects of capsaicin (CAP) on pain sensitivity and on the expression of capsaicin receptor, the vanilloid receptor (VR1), in rats. High-dose application of CAP has been known to degenerate a large fraction of the sensory neurons. Although the neurotoxic effects of CAP are well documented...

journal_title：Archives of pharmacal research

authors： Lee SY,Hong Y,Oh U

更新日期：2004-11-01 00:00:00